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專家人才

  • 姓名: 劉興國
  • 性別: 男
  • 職稱: 研究員
  • 學歷: 博士
  • 電話: 
  • 傳真: 
  • 電子郵件: liu_xingguo@gibh.ac.cn
  • 通訊地址 廣州市開源大道190號

    簡歷:

  • 2002-2006年:清華大學生物科學與技術系,博士

    1998-2002年:山東大學生命科學學院,學士

    2007-2010: Thomas Jefferson University, 博士后

    2010年-至今: 中國科學院廣州生物醫藥與健康研究院 研究員

    研究領域:

  • ·干細胞命運調控中的核與線粒體等細胞器重塑

    ·人類線粒體疾病的病理與干細胞治療

    承擔科研項目情況:

  •  

    社會任職:

  •  

    “Science Bulletin(《科學通報》英文版)執行編委 

    亞洲線粒體研究與醫學學會  常務理事 

    中國生物物理學會 常務理事 

    獲獎及榮譽:

  • ·國家自然科學杰出青年基金

    ·國家重點研發計劃首席科學家

    ·廣東省科學技術獎自然科學一等獎(第一完成人)

    ·樹蘭醫學青年獎

    ·國家自然科學優秀青年基金

    ·長江學者獎勵計劃青年學者

    ·2016年干細胞青年研究員獎

    ·廣東省特支計劃-科技創新“領軍人才”

    ·廣東省自然科學杰出青年基金獲得者(首屆)

    ·國際生物物理學會 "2011 Young Bioenergeticist award"

    ·中國科學院廣州教育基地優秀研究生導師

    ·中國科學院廣州分院優秀青年科學家

    ·臻溪生命科學優秀教育工作者獎教金

    代表論著:

  • 1.     Ying, Z., Xiang G., Zheng, L., …Liu, X*. (2018). Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming. Cell Metabolism, 28(6):935-945.

    2.     Ying, Z., Chen K., Zheng, L., …Liu, X*. (2016). Transient activation of mitoflashes modulates Nanog at the early phase of somatic cell reprogramming. Cell Metabolism, 23(1):220-226.

    3.     Li, L., Chen, K., Wang, T., …Liu, X*. (2020). Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism 2(9):882-892.

    4.     Long, Q., Zhou, Y., Wu, H., …Liu, X*. (2021). Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation. Nature Structural & Molecular Biology 28(11):900-908.

    5.     Bao, F., Zhou, L., Zhou, R., …Tian, M*&Liu, X*. (2022). Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances, in press.

    6.     Wu, Y., Chen, K., Xing, G., …Liu, X*. (2019). Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition. Science Advances, 5(11):eaax7525.

    7.     Guo, J., Duan, L., He, X., …Liu, X*. (2021). A combined model of human iPSC-derived liver organoids and hepatocytes reveals ferroptosis in DGUOK mutant mtDNA depletion syndrome. Advanced Science 8(10):2004680. (封面)

    8.     Xing, G., Liu, Z., Huang L., …Pei, D* Liu, X* & Chen, K*. (2021). MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening. Cell Death & Differentiation, November 24 online, DOI: 10.1038/s41418-021-00902-z.

    9.     Li, S., Guo, J., Ying, Z., ... Liu, X*. (2015). Valproic acid‐induced hepatotoxicity in Alpers syndrome is associated with mitochondrial permeability transition pore opening‐dependent apoptotic sensitivity in an induced pluripotent stem cell model. Hepatology, 61(5):1730-1739.

    10. Xiang, G., Yang, L., Long, Q., …Liu, X*. (2017). BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming. Autophagy, 13(9):1543-1555.

    11. Zhou, Y., Long, Q., Wu, H., …Liu, X*. (2020). Topology-dependent, bifurcated mitochondrial quality control under starvation. Autophagy, 16(3):562-574. (封面)

    12. Chen, K., Long, Q., Xing, G., …Pei, D*& Liu, X*. (2020). Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO Journal, 39(1):e99165 (F1000推薦)

    13. Chen, K., Long, Q., Wang, T., … Liu, X* & Pei, D*. (2016). Gadd45a is a heterochromatin relaxer that enhances iPS cell generation. EMBO Reports,17(11): 1641-1656.

    14. Yang, L., Lin, X., Tang, H.,....Liu, X*. (2020).  Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox. Aging Cell 19(9):e13206.

    15. Yang, L., Long, Q., Liu, J., ... Liu, X*. (2015). Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA. Cellular and Molecular Life Sciences, 72(13):2585-2598.

    16. Bao, F., Shi, H., Gao, M.,…Liu, X*. (2018). Polybrene induces neural degeneration by bidirectional Ca2+ influx dependent mitochondrial and ER-mitochondrial dynamics. Cell Death & Disease, 9(10):966.

    17. Li, L., Chen, K., Wu Y.,...Liu, X*. (2017). Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction. Cell Death & Disease, 8(10):e3107.

    18. Lin, Y., Xiao, M., Chen, H., Meng, Y., Zhao, N., Yang, L., Tang, H., Wang, J., Liu, X*, Zhu, Y.*, Zhuang, S.*. (2019). A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation. Cell Death & Disease, 10(7):528

    19. Wu, Y., Chen, K., Liu, X., ... Liu, X*. (2015). Srebp‐1 Interacts with c‐Myc to Enhance Somatic Cell Reprogramming. Stem Cells, 34(1): 83-92.

    20. Yang, L., Tang, H., Lin, X....Liu, X*. (2020). OPA1-Exon4b binds to mtDNA D-loop for transcriptional and metabolic modulation, independent of mitochondrial fusion. Frontiers in Cell and Developmental Biology, 8: 180.

    21. Long, Q., Zhao, D., Fan, W., ... Wang X* & Liu, X*. (2015). Modeling of Mitochondrial Donut Formation. Biophysical Journal, 109(5):892-899.

    22. Bao, F., Shi, H., Long, Q., …Liu, X*. (2016). Mitochondrial Membrane Potential-dependent Endoplasmic Reticulum Fragmentation is an Important Step in Neuritic Degeneration. CNS Neuroscience & Therapeutics 22(8):648-660.  ()

    23. Yao, D., Li, Y., Zeng, S., Liu, X*. (2021). Short-form OPA1 is a molecular chaperon in mitochondrial intermembrane space. Science China-Life Sciences Aug 31 online https://doi.org/10.1007/s11427-021-1962-0 (封面).

    24. Liu, W., Long, Q., Chen, K., ... & Liu, X*. (2013). Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation. Biochemical and Biophysical Research Communications, 431(4), 767-771.

    25. Liu, X., Weaver, D., Shirihai, O., & Hajnóczky, G. (2009). Mitochondrial ‘kissandrun’: interplay between mitochondrial motility and fusion–fission dynamics. The EMBO Journal, 28(20), 3074-3089. (F1000推薦)

    26. Liu, X., & Hajnoczky, G. (2011). Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress. Cell Death & Differentiation, 18(10), 1561-1572. (F1000推薦)

    27. Weaver, D., Eisner, V., Liu, X., … & Hajnóczky, G. (2014). Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion. Molecular Cell, 54(5), 870-878. (co-first author)

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